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Britain's Geraint Thomas is out of contention for the Giro d'Italia after losing more than 12 minutes on stage three to Mount Etna.
The Ineos Grenadiers rider, 34, crashed just before the start after a drinks bottle became lodged under his front wheel.
Fellow Briton and race favourite Simon Yates of Michelton-Scott lost more than four minutes.
The stage was won by EF Pro Cycling's Jonathan Caicedo.
Deceuninck-Quick Step's Joao Almeida now wears the leader's pink jersey, although he is tied on time with Caicedo.
What happened to Thomas and Yates?
Thomas - Tour de France champion in 2018 - and Yates were the two strongest contenders to win this year's Giro, which promised to be a battle of two riders coming into form.
Instead, it was a miserable day for both as the rain fell in the dramatic surrounds of Etna's dried black lava flows.
Welshman Thomas crashed during the neutralised zone before the start of the mountainous stage up to Sicily's volcano.
He appeared to be riding comfortably despite badly torn kit and landing on his hip.
But Thomas slipped back from the peloton about 25km from the end of the stage.
Ineos even sacrificed the leader's pink jersey, taking race leader Filippo Ganna back to try to help Thomas recover.
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