The series, believably showing the mechanisms of the work of the world drug trafficking, is based on the bestseller by Roberto Saviano. The storyline is based on the Don Muno mafia clan, which systematically smuggles cocaine, as well as an operative named Vampiro. The latter secretly works for drug lords and seeks to organize the traffic of the main party for Don Muno's clan. At the same time, a special drug squad in Mexico City conducts a special operation to prevent the transfer of the party and capture the clan. Among other things, Muno's grandson Stefano hates his grandfather and wants to hand him over to the police.